APPLICATIONS

DNA Integrity

Understand the Breakome with unbiased genome-wide detection of DNA breaks

DNA double-strand breaks (DSBs) occur naturally within cells but also arise from drugs, radiation and defects in DNA repair. Understanding where these breaks occur is fundamental for studying DNA integrity, genome stability and disease.

Originally developed for genome editing, ��ٱ��䷡-��® is fundamentally a technology for detecting DSBs, supporting research of the DNA damage response, genotoxicity, cancer, neurodegeneration and beyond.

��ٱ��䷡-��® provides unbiased, genome-wide mapping of the Breakome, the complete landscape of DNA DSBs from both endogenous and treatment-induced sources.

Compatible with a wide range of cell types, including patient-derived cells and iPSCs, the scalable workflow enables researchers to compare multiple conditions in parallel with a rapid turnaround.

Challenges with current approaches:

Traditional genotoxicity assays often rely on costly animal models

Imaging methods measure DNA damage without mapping breaks

Many sequencing methods are complex, PCR-biased & research-only

Some methods have limited compatibility with biologically relevant cells

Low-throughput workflows make comparing conditions difficult

With ��ٱ��䷡-��® you can:

Reduce reliance on animal models in many DNA damage studies

Directly map DNA break locations across the genome without bias

Generate unbiased, genome-wide data for downstream studies

Work with a wide range of cell types

Screen multiple treatments or conditions in parallel

Designed for flexible DNA integrity research

Assess DNA breaks directly in your cell type of interest

Compare genome-wide DNA damage across conditions

Generate data for bespoke downstream analysis

Investigate mechanisms of genome stability and DNA repair

Proven and trusted technology

��ٱ��䷡-��® has supported studies investigating DNA damage across multiple areas including cancer biology, drug-induced genotoxicity, genome editing, DNA replication and DNA repair.