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Services with INDUCE-seq®

Induce-seq® Gene Editing Analysis: Fast, Simultaneous On-Target & Off-Target Detection – Fully Outsourced

Gene Editing Analysis

INDUCE-seq® is a scalable, PCR-free platform simultaneous detection of both on-target and off-target DNA breaks induced during genome editing. Delivering data in as little as 2 days from sample submission, this cell-based assay offers single-nucleotide resolution, capturing each DNA break with a single sequencing read. Designed for high sensitivity, reproducibility, and genome-wide, unbiased detection, INDUCE-seq® is compatible with any gene editing system and adaptable to all cell types, including primary cells, iPSCs, and immortalized cells from diverse tissues.

  • On- and off-target assessment
  • Editing kinetic analysis
  • Guide screening
  • Nuclease development
  • Editing strategy optimizations

Full-Service Gene Editing Safety Assessments

Induce-seq® is available through a full-service partnership with ¶¶Òõ¶ÌÊÓƵ, delivering expert off-target analysis to support the safety and efficacy of gene and gene-edited cell therapies. This highly scalable and customizable service enables rapid, high-resolution mapping of DNA breaks, ensuring confident decision-making during IND-enabling studies and program scale-up.

Why CGT Developers Choose INDUCE-seq®

INDUCE-seq® delivers the industry’s most comprehensive and accurate on- and off-target characterization service, enabling pharmaceutical companies to make confident go/no-go decisions early in discovery while minimizing regulatory risk throughout development.

  • Comprehensive detection: Quantifies on/off target DSBs across the genome.
  • Cost Savings: Reduce R&D timelines and risk of regulatory holds due to off-target effects.
  • Cell-based assay: Compatible with all relevant cell types, including primary cells, iPSCs, T-cells, and immortalized cells from diverse tissues.
  • Single-nucleotide resolution: Precise DSB detection at the single nucleotide level.
  • PCR-free workflow: Directly measure DSBs without amplification bias, 1 read = 1 break.
  • Fast turnaround: Sample to insights in days.
  • Universal compatibility: Technology is compatible with any gene editing system.
  • Automation capability: Integrate with industry-standard automation systems.
  • Customizable: Collaboratively define the analysis parameters that suit any application.
Learn More about INDUCE-seq® Services

INDUCE-seq® On-Demand is now available for clients to bring the power of gene editing analysis into their own labs. INDUCE-seq® On-Demand offers the same high accuracy and efficiency in detecting on-and off-target effects while providing maximum control over timelines, IP and experimental design. Learn more about INDUCE-seq® On-Demand here.